We welcome everyone to come hear our talks/visit our posters at this year’s Retinal Cell and Gene Therapy Innovation Summit, ARVO and ASGCT meetings. Below is a list of all the Boye Lab projects being presented:
- “Identification of AAV capsid variants with enhanced retinal transduction following screening in non-human primate”. 4th Annual Retinal Cell and Gene Therapy Innovation Summit 2017
- AAV5 made by rHSV complementation displays increased retinal transduction relative to AAV5 made by plasmid transfection. Kevin T. Mccullough, Laura Adamson-Small, James Peterson, Sanford Boye, Nathalie Clément, Shannon E. Boye. ARVO 2017
- Directed Evolution of Enhanced AAV Capsid Variants Following Intravitreal Injection in Macaque. Sanford L. Boye, Shreyasi Choudhury, Damien Marsic, Christianne E. Strang, John J. Alexander, C. Douglas Witherspoon, Sergei Zolotukhin, Paul D. Gamlin, Shannon E. Boye. ARVO 2017
- Investigating the utility of mice as a model for developing clinically relevant dual AAV vectors to treat USH1B. Kaitlyn Calabro, Sanford Boye, Kevin T. Mccullough, Shreyasi Choudhury, Paul D. Gamlin, Shannon E. Boye. ARVO 2017
- Novel AAV variants isolated by directed evolution in primate display enhanced retinal transduction following intravitreal injection. Shreyasi Choudhury, Damien Marsic, James Peterson, Diego Fajardo, Antonette Bennett, Paul D. Gamlin, Mavis Agbandje-McKenna, Sergei Zolotukhin, Sanford L. Boye, Shannon E. Boye. ARVO 2017
- Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors. Christine Harman, Kristin Koehl, Annie Oh, Vince A. Chiodo, Sanford L. Boye, William W. Hauswirth, Shannon E. Boye, Andras M. Komaromy. ARVO 2017
- Efficient In Vivo Gene Editing of Inherited Retinal Disease Genes in Mice and Non-Human Primates. Shannon E. Boye, Michael Stefanidakis, Rina Mepani, Maxwell N. Skor, Sebastian W. Gloskowski, Joy Horng, Kevin T. McCullough, Eugenio Marco, Georgia Giannoukos, Dawn Ciulla, Hoson Chao, George S. Bounoutas, C. Douglas Witherspoon, Christopher Wilson, David Bumcrot, Paul Gamlin, Sanford Boye, Haiyan Jiang, Charlie Albright, Morgan L. Maeder. ASGCT 2017
- NGS and Bioinformatics Pipeline for Targeted AAV Delivery by Directed Capsid Evolution. Damien Marsic, Sanford L. Boye, Shannon E. Boye, Sergei Zolotukhin. ASGCT 2017
- Novel AAV Variants Isolated by Directed Evolution in Primate Display Enhanced Retinal Transduction Following Intravitreal Injection. Sanford L. Boye, Shreyasi Choudhury, Damien Marsic, Christianne Strang, James J. Peterson, Diego Fajardo, Antonette Bennett, Mavis Agbandje-McKenna, C. Douglas Witherspoon, Paul D. Gamlin, Sergei Zolotukhin, Shannon E. Boye. ASGCT 2017
- IND-Enabling Studies En Route to a Gene Therapy for GUCY2D Leber Congenital Amaurosis (LCA1). Shannon E. Boye, Sanford L. Boye, Samuel G. Jacobson, James J. Peterson, Diego Fajardo, K. Tyler McCullough, Catherine O’Riordan, Michael Lukason, Jim Morris, Rena Baek, Seng Cheng, Abraham Scaria, Alison McVie-Wylie. ASGCT 2017